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Research Article

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

  • John E. Tavis mail,

    tavisje@slu.edu

    Affiliations: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Xiaohong Cheng equal contributor,

    equal contributor Contributed equally to this work with: Xiaohong Cheng, Yuan Hu

    Affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Yuan Hu equal contributor,

    equal contributor Contributed equally to this work with: Xiaohong Cheng, Yuan Hu

    Affiliations: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Key Laboratory of Molecular Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China

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  • Michael Totten,

    Affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Feng Cao,

    Affiliations: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Eleftherios Michailidis,

    Affiliation: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America

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  • Rajeev Aurora,

    Affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Marvin J. Meyers,

    Affiliation: Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • E. Jon Jacobsen,

    Affiliation: Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Michael A. Parniak,

    Affiliation: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America

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  • Stefan G. Sarafianos

    Affiliation: Department of Molecular Microbiology and Immunology and Department of Biochemistry, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center, Columbia, Missouri, United States of America

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  • Published: January 22, 2013
  • DOI: 10.1371/journal.ppat.1003125

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