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Research Article

Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

  • Nicolas Dreux,

    Affiliation: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France

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  • Jérémy Denizot,

    Affiliation: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France

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  • Margarita Martinez-Medina,

    Affiliation: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France

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  • Alexander Mellmann,

    Affiliation: Institute of Hygiene, University Hospital Münster, Münster, Germany

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  • Maria Billig,

    Affiliation: University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America

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  • Dagmara Kisiela,

    Affiliation: University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America

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  • Sujay Chattopadhyay,

    Affiliation: University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America

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  • Evgeni Sokurenko,

    Affiliation: University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America

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  • Christel Neut,

    Affiliation: Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France

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  • Corinne Gower-Rousseau,

    Affiliation: Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France

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  • Jean-Frédéric Colombel,

    Affiliation: Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France

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  • Richard Bonnet,

    Affiliations: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Service de Bactériologie, CHU, Clermont-Ferrand, France

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  • Arlette Darfeuille-Michaud,

    Affiliations: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Service de Bactériologie, CHU, Clermont-Ferrand, France, Institut Universitaire de Technologie, Génie Biologique, Aubière, France

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  • Nicolas Barnich mail

    nicolas.barnich@u-clermont1.fr

    Affiliations: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Institut Universitaire de Technologie, Génie Biologique, Aubière, France

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.ppat.1003141

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