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Research Article

A Small Molecule Glycosaminoglycan Mimetic Blocks Plasmodium Invasion of the Mosquito Midgut

  • Derrick K. Mathias equal contributor,

    equal contributor Contributed equally to this work with: Derrick K. Mathias, Rebecca Pastrana-Mena

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Rebecca Pastrana-Mena equal contributor,

    equal contributor Contributed equally to this work with: Derrick K. Mathias, Rebecca Pastrana-Mena

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Elisabetta Ranucci,

    Affiliation: Department of Chemistry, University of Milan, Milan, Italy

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  • Dingyin Tao,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Paolo Ferruti,

    Affiliation: Department of Chemistry, University of Milan, Milan, Italy

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  • Corrie Ortega,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Gregory O. Staples,

    Affiliation: Department of Biochemistry and Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Joseph Zaia,

    Affiliation: Department of Biochemistry and Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Eizo Takashima,

    Affiliation: Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan

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  • Takafumi Tsuboi,

    Affiliation: Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan

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  • Natalie A. Borg,

    Affiliation: Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

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  • Luisella Verotta,

    Affiliation: Department of Chemistry, University of Milan, Milan, Italy

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  • Rhoel R. Dinglasan mail

    rdinglas@jhsph.edu

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Published: November 21, 2013
  • DOI: 10.1371/journal.ppat.1003757

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