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Research Article

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

  • Mark S. Gresnigt,

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Silvia Bozza,

    Affiliation: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

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  • Katharina L. Becker,

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Leo A. B. Joosten,

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Shahla Abdollahi-Roodsaz,

    Affiliation: Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Wim B. van der Berg,

    Affiliation: Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Charles A. Dinarello,

    Affiliations: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America

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  • Mihai G. Netea,

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Thierry Fontaine,

    Affiliation: Unité des Aspergillus, Institut Pasteur, Paris, France

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  • Antonella De Luca,

    Affiliation: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

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  • Silvia Moretti,

    Affiliation: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

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  • Luigina Romani mail,

    luigina.romani@unipg.it (LR); jean-paul.latge@pasteur.fr (JPL); frank.vandeveerdonk@aig.umcn.nl (FLvdV)

    Affiliation: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

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  • Jean-Paul Latge mail,

    luigina.romani@unipg.it (LR); jean-paul.latge@pasteur.fr (JPL); frank.vandeveerdonk@aig.umcn.nl (FLvdV)

    Affiliation: Unité des Aspergillus, Institut Pasteur, Paris, France

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  • Frank L. van de Veerdonk mail

    luigina.romani@unipg.it (LR); jean-paul.latge@pasteur.fr (JPL); frank.vandeveerdonk@aig.umcn.nl (FLvdV)

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003936

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