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Appendix II
We can also consider the other extreme where the effects of viral replication on the decay of the reservoir in the setting of HAART are maximized (i.e. the latent reservoir is at steady-state), described by regime (2). In this case the intrinsic decay rate of the reservoir is balanced by inflow into the reservoir. In this scenario intensification of HAART could maximize the reservoir decay rate by reducing EMBED Equation.3 to zero. We could therefore predict the maximum decay rate of the latent reservoir under intensified HAART as: EMBED Equation.3 = EMBED Equation.3 / EMBED Equation.3 , where EMBED Equation.3 is the maximum calculated inflow rate. The patient-averaged EMBED Equation.3 , under steady-state cases 5 and 6 (Table 3) for both standard and add-one likelihood estimates, was found to be between 0.000195 and 0.000531 day-1. Thus in the worst case scenario where the reservoir remains at steady-state due to ongoing viral replication in the setting of standard HAART, our results suggest that HAART intensification could at best cause the latent reservoir to decay with half-life of on average 43.5 to 118 months.
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