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Research Article

High Throughput Functional Assays of the Variant Antigen PfEMP1 Reveal a Single Domain in the 3D7 Plasmodium falciparum Genome that Binds ICAM1 with High Affinity and Is Targeted by Naturally Acquired Neutralizing Antibodies

  • Andrew V. Oleinikov mail,

    andrew.oleinikov@sbri.org

    Affiliation: Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Emily Amos,

    Affiliation: Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Isaac Tyler Frye,

    Affiliation: Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Eddie Rossnagle,

    Affiliation: Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Theonest K. Mutabingwa,

    Affiliations: Seattle Biomedical Research Institute, Seattle, Washington, United States of America, National Institute for Medical Research, Dar es Salaam, Tanzania

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  • Michal Fried,

    Affiliations: Seattle Biomedical Research Institute, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America

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  • Patrick E. Duffy

    Affiliations: Seattle Biomedical Research Institute, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America

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  • Published: April 17, 2009
  • DOI: 10.1371/journal.ppat.1000386

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