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Research Article

Intravenous Inoculation of a Bat-Associated Rabies Virus Causes Lethal Encephalopathy in Mice through Invasion of the Brain via Neurosecretory Hypothalamic Fibers

  • Mirjam A. R. Preuss,

    Affiliations: Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany, Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Marie-Luise Faber,

    Affiliation: Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Gene S. Tan,

    Affiliation: Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Michael Bette,

    Affiliation: Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany

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  • Bernhard Dietzschold,

    Affiliation: Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Eberhard Weihe equal contributor,

    equal contributor Contributed equally to this work with: Eberhard Weihe, Matthias J. Schnell

    Affiliation: Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany

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  • Matthias J. Schnell equal contributor mail

    equal contributor Contributed equally to this work with: Eberhard Weihe, Matthias J. Schnell

    matthias.schnell@jefferson.edu

    Affiliation: Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Published: June 19, 2009
  • DOI: 10.1371/journal.ppat.1000485

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