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Research Article

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

  • Thierry Christophe,

    Affiliation: Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Mary Jackson,

    Affiliation: Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Hee Kyoung Jeon,

    Affiliation: Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Denis Fenistein,

    Affiliation: Image Mining, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Monica Contreras-Dominguez,

    Affiliation: Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Jaeseung Kim,

    Affiliation: Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Auguste Genovesio,

    Affiliation: Image Mining, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Jean-Philippe Carralot,

    Affiliation: Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Fanny Ewann,

    Affiliation: Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Eun Hye Kim,

    Affiliation: Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Sae Yeon Lee,

    Affiliation: Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Sunhee Kang,

    Affiliation: Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Min Jung Seo,

    Affiliation: Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Eun Jung Park,

    Affiliation: Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Henrieta Škovierová,

    Affiliation: Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Ha Pham,

    Affiliation: Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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  • Giovanna Riccardi,

    Affiliation: Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, Pavia, Italy

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  • Ji Youn Nam,

    Affiliation: Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Laurent Marsollier,

    Affiliation: Groupe d'Etude des Interactions Hôte Pathogène, Université d'Angers, Angers, France

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  • Marie Kempf,

    Affiliation: Groupe d'Etude des Interactions Hôte Pathogène, Université d'Angers, Angers, France

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  • Marie-Laure Joly-Guillou,

    Affiliation: Groupe d'Etude des Interactions Hôte Pathogène, Université d'Angers, Angers, France

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  • Taegwon Oh,

    Affiliation: International Tuberculosis Research Center, Masan, Korea

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  • Won Kyung Shin,

    Affiliation: International Tuberculosis Research Center, Masan, Korea

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  • Zaesung No,

    Affiliation: Medicinal Chemistry, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Ulf Nehrbass,

    Affiliation: Screening Technologies and Pharmacology, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

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  • Roland Brosch,

    Affiliation: Institut Pasteur, Integrated Mycobacterial Pathogenomics, Paris, France

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  • Stewart T. Cole,

    Affiliation: Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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  • Priscille Brodin mail

    pbrodin@ip-korea.org

    Affiliations: Biology of Intracellular Pathogens Inserm Avenir Group, Institut Pasteur Korea, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea, Institut Pasteur, Integrated Mycobacterial Pathogenomics, Paris, France

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  • Published: October 30, 2009
  • DOI: 10.1371/journal.ppat.1000645

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