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Research Article

Structural and Biochemical Characterization of SrcA, a Multi-Cargo Type III Secretion Chaperone in Salmonella Required for Pathogenic Association with a Host

  • Colin A. Cooper,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Kun Zhang,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Sara N. Andres,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Yuan Fang,

    Affiliation: Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Natalia A. Kaniuk,

    Affiliation: Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Mandy Hannemann,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

    Current address: International Max Planck Research School for Molecular Biology, Göttingen, Germany

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  • John H. Brumell,

    Affiliations: Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics and the Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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  • Leonard J. Foster,

    Affiliation: Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Murray S. Junop,

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Brian K. Coombes mail

    coombes@mcmaster.ca

    Affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Published: February 05, 2010
  • DOI: 10.1371/journal.ppat.1000751

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