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Research Article

Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

  • Aisha Nazli,

    Affiliations: Center For Gene Therapeutics, Michael G. DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Olivia Chan,

    Affiliations: Center For Gene Therapeutics, Michael G. DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Wendy N. Dobson-Belaire,

    Affiliation: Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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  • Michel Ouellet,

    Affiliation: Department of Medical Biology, Laval University, Quebec City, Quebec, Canada

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  • Michel J. Tremblay,

    Affiliation: Department of Medical Biology, Laval University, Quebec City, Quebec, Canada

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  • Scott D. Gray-Owen,

    Affiliation: Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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  • A. Larry Arsenault,

    Affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Charu Kaushic mail

    kaushic@mcmaster.ca

    Affiliations: Center For Gene Therapeutics, Michael G. DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Published: April 08, 2010
  • DOI: 10.1371/journal.ppat.1000852

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