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Research Article

Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control

  • Adam R. Hersperger,

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Florencia Pereyra,

    Affiliation: Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, United States of America

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  • Martha Nason,

    Affiliation: Biostatistics Research Branch, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Korey Demers,

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Prameet Sheth,

    Affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Lucy Y. Shin,

    Affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Colin M. Kovacs,

    Affiliation: Canadian Immunodeficiency Research Collaborative, Toronto, Ontario, Canada

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  • Benigno Rodriguez,

    Affiliation: Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, United States of America

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  • Scott F. Sieg,

    Affiliation: Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, United States of America

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  • Leia Teixeira-Johnson,

    Affiliation: Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Debbie Gudonis,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Paul A. Goepfert,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Michael M. Lederman,

    Affiliation: Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, United States of America

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  • Ian Frank,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • George Makedonas,

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Rupert Kaul,

    Affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Bruce D. Walker,

    Affiliations: Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Michael R. Betts mail

    betts@mail.med.upenn.edu

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: May 27, 2010
  • DOI: 10.1371/journal.ppat.1000917

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