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Research Article

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

  • Shinya Yamada,

    Affiliation: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Masato Hatta,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Bart L. Staker,

    Affiliations: Emerald BioStructures, Inc., Bainbridge Island, Washington, United States of America, Seattle Structural Genomics Center for Infectious Disease, Washington, United States of America

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  • Shinji Watanabe,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Masaki Imai,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Kyoko Shinya,

    Affiliation: Department of Microbiology and Infectious Diseases, Kobe University, Hyogo, Japan

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  • Yuko Sakai-Tagawa,

    Affiliation: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Mutsumi Ito,

    Affiliation: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Makoto Ozawa,

    Affiliations: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Tokiko Watanabe,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Saori Sakabe,

    Affiliations: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, ERATO Infection-Induced Host Responses Project, Saitama, Japan

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  • Chengjun Li,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Jin Hyun Kim,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Peter J. Myler,

    Affiliations: Seattle Structural Genomics Center for Infectious Disease, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America, Departments of Global Health and Medical Education & Biomedical Informatics, University of Washington, Seattle, Washington, United States of America

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  • Isabelle Phan,

    Affiliations: Seattle Structural Genomics Center for Infectious Disease, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Amy Raymond,

    Affiliations: Emerald BioStructures, Inc., Bainbridge Island, Washington, United States of America, Seattle Structural Genomics Center for Infectious Disease, Washington, United States of America

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  • Eric Smith,

    Affiliations: Emerald BioStructures, Inc., Bainbridge Island, Washington, United States of America, Seattle Structural Genomics Center for Infectious Disease, Washington, United States of America

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  • Robin Stacy,

    Affiliations: Seattle Structural Genomics Center for Infectious Disease, Washington, United States of America, Seattle Biomedical Research Institute, Seattle, Washington, United States of America

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  • Chairul A. Nidom,

    Affiliations: Faculty of Veterinary Medicine, Tropical Disease Centre, Airlangga University, Surabaya, Indonesia, Collaborating Research Center-Emerging and Reemerging Infectious Diseases, Tropical Disease Centre, Airlangga University, Surabaya, Indonesia

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  • Simon M. Lank,

    Affiliation: Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Roger W. Wiseman,

    Affiliation: Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Benjamin N. Bimber,

    Affiliation: Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • David H. O'Connor,

    Affiliations: Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Gabriele Neumann,

    Affiliation: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Lance J. Stewart mail,

    kawaokay@svm.vetmed.wisc.edu (YK, for virological research aspects); lstewart@embios.com (LJS, for structural research aspects)

    Affiliations: Emerald BioStructures, Inc., Bainbridge Island, Washington, United States of America, Seattle Structural Genomics Center for Infectious Disease, Washington, United States of America

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  • Yoshihiro Kawaoka mail

    kawaokay@svm.vetmed.wisc.edu (YK, for virological research aspects); lstewart@embios.com (LJS, for structural research aspects)

    Affiliations: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Microbiology and Infectious Diseases, Kobe University, Hyogo, Japan, Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan, ERATO Infection-Induced Host Responses Project, Saitama, Japan, Creative Research Initiative, Sousei, Hokkaido University, Sapporo, Japan

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  • Published: August 05, 2010
  • DOI: 10.1371/journal.ppat.1001034

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