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Research Article

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

  • Markus Schrettl,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Nicola Beckmann,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • John Varga,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America, and The George Washington University School of Medicine, Department of Biochemistry and Molecular Biology, Washington, D.C., United States of America

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  • Thorsten Heinekamp,

    Affiliation: Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany

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  • Ilse D. Jacobsen,

    Affiliation: Department for Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany

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  • Christoph Jöchl,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Tarek A. Moussa,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Shaohua Wang,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Fabio Gsaller,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Michael Blatzer,

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Ernst R. Werner,

    Affiliation: Division of Biological Chemistry/Biocenter, Medical University Innsbruck, Innsbruck, Austria

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  • William C. Niermann,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America, and The George Washington University School of Medicine, Department of Biochemistry and Molecular Biology, Washington, D.C., United States of America

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  • Axel A. Brakhage,

    Affiliation: Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Friedrich Schiller University Jena, Jena, Germany

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  • Hubertus Haas mail

    hubertus.haas@i-med.ac.at

    Affiliation: Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria

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  • Published: September 30, 2010
  • DOI: 10.1371/journal.ppat.1001124

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