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Research Article

Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41

  • Elena Gustchina equal contributor,

    equal contributor Contributed equally to this work with: Elena Gustchina, Mi Li, John M. Louis

    Affiliation: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Mi Li equal contributor,

    equal contributor Contributed equally to this work with: Elena Gustchina, Mi Li, John M. Louis

    Affiliations: Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Frederick, Maryland, United States of America

    X
  • John M. Louis equal contributor,

    equal contributor Contributed equally to this work with: Elena Gustchina, Mi Li, John M. Louis

    Affiliation: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • D. Eric Anderson,

    Affiliation: Proteomics and Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • John Lloyd,

    Affiliation: Proteomics and Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Christian Frisch,

    Affiliation: AbD Serotec, MorphoSys AG, Martinsried, Germany

    X
  • Carole A. Bewley,

    Affiliation: Laboratory of Biorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Alla Gustchina mail,

    mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW); gustchia@mail.nih.gov (AG)

    Affiliation: Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • Alexander Wlodawer mail,

    mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW); gustchia@mail.nih.gov (AG)

    Affiliation: Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • G. Marius Clore mail

    mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW); gustchia@mail.nih.gov (AG)

    Affiliation: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: November 11, 2010
  • DOI: 10.1371/journal.ppat.1001182

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