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Research Article

The Antiviral Efficacy of HIV-Specific CD8+ T-Cells to a Conserved Epitope Is Heavily Dependent on the Infecting HIV-1 Isolate

  • Srinika R. F. Ranasinghe mail,

    tao.dong@imm.ox.ac.uk (TD); srinika.ranasinghe@bnc.oxon-org (SRFR)

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

    Current address: The Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Holger B. Kramer,

    Affiliation: Henry Wellcome Building of Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

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  • Cynthia Wright,

    Affiliation: Henry Wellcome Building of Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

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  • Benedikt M. Kessler,

    Affiliation: Henry Wellcome Building of Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

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  • Katalin di Gleria,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Yonghong Zhang,

    Affiliations: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, BeiJing You'An Hospital, BeiJing Capital University, BeiJing, China

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  • Geraldine M. Gillespie,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Marie-Eve Blais,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Abigail Culshaw,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Tica Pichulik,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Alison Simmons,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Sarah L. Rowland-Jones,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Andrew J. McMichael,

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Tao Dong mail

    tao.dong@imm.ox.ac.uk (TD); srinika.ranasinghe@bnc.oxon-org (SRFR)

    Affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • Published: May 12, 2011
  • DOI: 10.1371/journal.ppat.1001341

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