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Research Article

AAV Exploits Subcellular Stress Associated with Inflammation, Endoplasmic Reticulum Expansion, and Misfolded Proteins in Models of Cystic Fibrosis

  • Jarrod S. Johnson,

    Affiliations: Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Martina Gentzsch,

    Affiliations: Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Liqun Zhang,

    Affiliations: Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Carla M. P. Ribeiro,

    Affiliations: Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Boris Kantor,

    Affiliation: Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Tal Kafri,

    Affiliations: Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Raymond J. Pickles,

    Affiliations: Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • R. Jude Samulski mail

    rjs@med.unc.edu

    Affiliations: Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Published: May 19, 2011
  • DOI: 10.1371/journal.ppat.1002053

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