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Research Article

13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation

  • Dany J. V. Beste,

    Affiliation: School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom

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  • Bhushan Bonde,

    Affiliation: School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom

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  • Nathaniel Hawkins,

    Affiliation: Rothamsted Research, National Centre for Plant and Microbial Metabolomics, Harpenden, Herts, United Kingdom

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  • Jane L. Ward,

    Affiliation: Rothamsted Research, National Centre for Plant and Microbial Metabolomics, Harpenden, Herts, United Kingdom

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  • Michael H. Beale,

    Affiliation: Rothamsted Research, National Centre for Plant and Microbial Metabolomics, Harpenden, Herts, United Kingdom

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  • Stephan Noack,

    Affiliation: Forschungszentrum Jülich GmbH, Institute of Bio- and Geosciences 1: Biotechnology 2, Jülich, Germany

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  • Katharina Nöh,

    Affiliation: Forschungszentrum Jülich GmbH, Institute of Bio- and Geosciences 1: Biotechnology 2, Jülich, Germany

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  • Nicholas J. Kruger,

    Affiliation: Department of Plant Sciences, University of Oxford, Oxford, United Kingdom

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  • R. George Ratcliffe,

    Affiliation: Department of Plant Sciences, University of Oxford, Oxford, United Kingdom

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  • Johnjoe McFadden mail

    j.mcfadden@surrey.ac.uk

    Affiliation: School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom

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  • Published: July 21, 2011
  • DOI: 10.1371/journal.ppat.1002091

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