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Research Article

The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile

  • Glen P. Carter,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Gillian R. Douce,

    Affiliation: Division of Infection and Immunity, FBLS Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Revathi Govind,

    Affiliation: Division of Biology, Kansas State University, Manhattan, Kansas, United States of America

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  • Pauline M. Howarth,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Kate E. Mackin,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Janice Spencer,

    Affiliation: Division of Infection and Immunity, FBLS Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Anthony M. Buckley,

    Affiliation: Division of Infection and Immunity, FBLS Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Ana Antunes,

    Affiliation: Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, Paris, France

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  • Despina Kotsanas,

    Affiliation: Department of Infectious Diseases, Southern Health, Monash Medical Centre, Clayton, Victoria, Australia

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  • Grant A. Jenkin,

    Affiliation: Department of Infectious Diseases, Southern Health, Monash Medical Centre, Clayton, Victoria, Australia

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  • Bruno Dupuy,

    Affiliation: Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, Paris, France

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  • Julian I. Rood,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Dena Lyras mail

    Dena.Lyras@monash.edu

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Published: October 13, 2011
  • DOI: 10.1371/journal.ppat.1002317

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