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Research Article

PK-sensitive PrPSc Is Infectious and Shares Basic Structural Features with PK-resistant PrPSc

  • Gustavo Sajnani mail,

    gsajnani@sescam.jccm.es

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

    Current address: Neural Repair and Biomaterials Lab, National Paraplegia Hospital, Toledo, Spain

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  • Christopher J. Silva,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

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  • Adriana Ramos,

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

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  • Miguel A. Pastrana,

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

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  • Bruce C. Onisko,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

    Current address: OniPro, Kensington, California, United States of America

    X
  • Melissa L. Erickson,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

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  • Elizabeth M. Antaki,

    Affiliations: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America, Department of Pathology, University of California, Davis, Davis, California, United States of America

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  • Irina Dynin,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

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  • Ester Vázquez-Fernández,

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

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  • Christina J. Sigurdson,

    Affiliations: Department of Pathology, University of California, Davis, Davis, California, United States of America, Department of Pathology, University of California, San Diego, La Jolla, California, United States of America

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  • J. Mark Carter,

    Affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California, United States of America

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  • Jesús R. Requena

    Affiliation: Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Galiza, Spain

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.ppat.1002547

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