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Research Article

Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections

  • Clarissa Pozzi equal contributor,

    equal contributor Contributed equally to this work with: Clarissa Pozzi, Elaine M. Waters

    Affiliations: UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Elaine M. Waters equal contributor,

    equal contributor Contributed equally to this work with: Clarissa Pozzi, Elaine M. Waters

    Affiliations: UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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  • Justine K. Rudkin,

    Affiliation: Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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  • Carolyn R. Schaeffer,

    Affiliations: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Amanda J. Lohan,

    Affiliations: UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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  • Pin Tong,

    Affiliations: UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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  • Brendan J. Loftus,

    Affiliations: UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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  • Gerald B. Pier,

    Affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Paul D. Fey,

    Affiliations: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Ruth C. Massey,

    Affiliation: Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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  • James P. O'Gara mail

    jim.ogara@ucd.ie

    Affiliations: UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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  • Published: April 05, 2012
  • DOI: 10.1371/journal.ppat.1002626

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