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Research Article

Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

  • Zhen-yong Keck,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Jinming Xia,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Yong Wang,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Wenyan Wang,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Thomas Krey,

    Affiliation: Institut Pasteur, CNRS URA3015, Unite de Virologie Structurale, Paris, France

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  • Jannick Prentoe,

    Affiliations: Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Thomas Carlsen,

    Affiliations: Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Angela Ying-Jian Li,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Arvind H. Patel,

    Affiliation: MRC – University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

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  • Stanley M. Lemon,

    Affiliation: Lineberger Comprehensive Cancer Center and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Jens Bukh,

    Affiliations: Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Felix A. Rey,

    Affiliation: Institut Pasteur, CNRS URA3015, Unite de Virologie Structurale, Paris, France

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  • Steven K. H. Foung mail

    sfoung@stanford.edu

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: April 12, 2012
  • DOI: 10.1371/journal.ppat.1002653

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