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Research Article

Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape

  • Katharine J. Bar,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Chun-yen Tsao,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Shilpa S. Iyer,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Julie M. Decker,

    Affiliation: University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Yongping Yang,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Mattia Bonsignori,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Xi Chen,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Kwan-Ki Hwang,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • David C. Montefiori,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Hua-Xin Liao,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Peter Hraber,

    Affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • William Fischer,

    Affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Hui Li,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Shuyi Wang,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Sarah Sterrett,

    Affiliation: University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Brandon F. Keele,

    Affiliation: SAIC-Frederick Inc, National Cancer Institute, Frederick, Maryland, United States of America

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  • Vitaly V. Ganusov,

    Affiliation: University of Tennessee, Knoxville, Tennessee, United States of America

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  • Alan S. Perelson,

    Affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Bette T. Korber,

    Affiliation: Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Ivelin Georgiev,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jason S. McLellan,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jeffrey W. Pavlicek,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Feng Gao,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Barton F. Haynes,

    Affiliation: Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Beatrice H. Hahn,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Peter D. Kwong,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • George M. Shaw mail

    shawg@upenn.edu

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: May 31, 2012
  • DOI: 10.1371/journal.ppat.1002721

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