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Research Article

Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

  • Ursula Neu equal contributor,

    equal contributor Contributed equally to this work with: Ursula Neu, Holger Hengel

    Affiliation: Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, Germany

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  • Holger Hengel equal contributor,

    equal contributor Contributed equally to this work with: Ursula Neu, Holger Hengel

    Affiliation: Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, Germany

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  • Bärbel S. Blaum,

    Affiliations: Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, Germany, Department of Chemistry, University of Luebeck, Luebeck, Germany

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  • Rachel M. Schowalter,

    Affiliation: Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Dennis Macejak,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, and the Biofrontiers Institute, University of Colorado at Boulder, Boulder, Colorado, United States of America

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  • Michel Gilbert,

    Affiliation: National Research Council Canada, Institute for Biological Sciences, Glycobiology Program, Ottawa, Ontario, Canada

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  • Warren W. Wakarchuk,

    Affiliation: National Research Council Canada, Institute for Biological Sciences, Glycobiology Program, Ottawa, Ontario, Canada

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  • Akihiro Imamura,

    Affiliations: Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan, Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan

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  • Hiromune Ando,

    Affiliations: Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan, Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan

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  • Makoto Kiso,

    Affiliations: Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan, Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan

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  • Niklas Arnberg,

    Affiliation: Division of Virology, Department of Clinical Microbiology, Umeå University, Umeå, Sweden

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  • Robert L. Garcea,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, and the Biofrontiers Institute, University of Colorado at Boulder, Boulder, Colorado, United States of America

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  • Thomas Peters,

    Affiliation: Department of Chemistry, University of Luebeck, Luebeck, Germany

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  • Christopher B. Buck,

    Affiliation: Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Thilo Stehle mail

    thilo.stehle@uni-tuebingen.de

    Affiliations: Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, Germany, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002738

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