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Research Article

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection

  • Sara Rodríguez-Martín equal contributor,

    equal contributor Contributed equally to this work with: Sara Rodríguez-Martín, Kai Alexander Kropp

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Kai Alexander Kropp equal contributor,

    equal contributor Contributed equally to this work with: Sara Rodríguez-Martín, Kai Alexander Kropp

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Vanessa Wilhelmi,

    Affiliation: Institute for Virology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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  • Vanda Juranic Lisnic,

    Affiliation: Department of Histology and Embryology/Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia

    X
  • Wei Yuan Hsieh,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Mathieu Blanc,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Andrew Livingston,

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

    X
  • Andreas Busche,

    Affiliation: Department of Virology, Hannover Medical School, Hannover, Germany

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  • Hille Tekotte,

    Affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

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  • Martin Messerle,

    Affiliation: Department of Virology, Hannover Medical School, Hannover, Germany

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  • Manfred Auer,

    Affiliation: University of Edinburgh, School of Biological Sciences (CSE) and School of Biomedical Sciences (CMVM), Edinburgh, United Kingdom

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  • Iain Fraser,

    Affiliation: Laboratory of Systems Biology, National Institution of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Stipan Jonjic,

    Affiliation: Department of Histology and Embryology/Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia

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  • Ana Angulo,

    Affiliation: Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain

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  • Matthias J. Reddehase,

    Affiliation: Institute for Virology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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  • Peter Ghazal mail

    p.ghazal@ed.ac.uk

    Affiliation: Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.ppat.1002901

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