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Research Article

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

  • Erhard van der Vries,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Patrick J. Collins,

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Sebastien G. Vachieri,

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Xiaoli Xiong,

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Junfeng Liu,

    Affiliations: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom, MOA Key Laboratory of Plant Pathology, China Agricultural University, Beijing, People's Republic of China

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  • Philip A. Walker,

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Lesley F. Haire,

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Alan J. Hay,

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Martin Schutten,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Albert D. M. E. Osterhaus,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Steve R. Martin,

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Charles A. B. Boucher,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • John J. Skehel mail,

    skeheljj@nimr.mrc.ac.uk

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Steve J. Gamblin

    Affiliation: Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

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  • Published: September 20, 2012
  • DOI: 10.1371/journal.ppat.1002914

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