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Research Article

SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens

  • Ho Pan Sham,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Emily Yi Shan Yu,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Muhammet F. Gulen,

    Affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

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  • Ganive Bhinder,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Martin Stahl,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Justin M. Chan,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Lara Brewster,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Vijay Morampudi,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Deanna L. Gibson,

    Affiliation: Department of Biology, University of British Columbia Okanagan, Kelowna, British Columbia, Canada

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  • Michael R. Hughes,

    Affiliation: Department of Medical Genetics, Biomedical Research Center, University of British Columbia, Vancouver, British Columbia, Canada

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  • Kelly M. McNagny,

    Affiliation: Department of Medical Genetics, Biomedical Research Center, University of British Columbia, Vancouver, British Columbia, Canada

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  • Xiaoxia Li mail,

    lix@ccf.org (XL); bvallance@cw.bc.ca (BAV)

    Affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

    X
  • Bruce A. Vallance mail

    lix@ccf.org (XL); bvallance@cw.bc.ca (BAV)

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: August 08, 2013
  • DOI: 10.1371/journal.ppat.1003539

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