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Research Article

VE-Cadherin Cleavage by LasB Protease from Pseudomonas aeruginosa Facilitates Type III Secretion System Toxicity in Endothelial Cells

  • Guillaume Golovkine,

    Affiliations: INSERM, U1036, Biology of Cancer and Infection, Grenoble, France, CNRS, ERL 5261, Bacterial Pathogenesis and Cellular Responses, Grenoble, France, Université Joseph Fourier-Grenoble I, Grenoble, France, CEA, DSV/iRTSV, Grenoble, France

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  • Eric Faudry,

    Affiliations: INSERM, U1036, Biology of Cancer and Infection, Grenoble, France, CNRS, ERL 5261, Bacterial Pathogenesis and Cellular Responses, Grenoble, France, Université Joseph Fourier-Grenoble I, Grenoble, France, CEA, DSV/iRTSV, Grenoble, France

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  • Stéphanie Bouillot,

    Affiliations: INSERM, U1036, Biology of Cancer and Infection, Grenoble, France, CNRS, ERL 5261, Bacterial Pathogenesis and Cellular Responses, Grenoble, France, Université Joseph Fourier-Grenoble I, Grenoble, France, CEA, DSV/iRTSV, Grenoble, France

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  • Romé Voulhoux,

    Affiliation: CNRS and Aix-Marseille Univ, Laboratoire d'Ingénierie des Systèmes Macromoléculaires (UMR7255), Marseille, France

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  • Ina Attrée,

    Affiliations: INSERM, U1036, Biology of Cancer and Infection, Grenoble, France, CNRS, ERL 5261, Bacterial Pathogenesis and Cellular Responses, Grenoble, France, Université Joseph Fourier-Grenoble I, Grenoble, France, CEA, DSV/iRTSV, Grenoble, France

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  • Philippe Huber mail

    phuber@cea.fr

    Affiliations: INSERM, U1036, Biology of Cancer and Infection, Grenoble, France, CNRS, ERL 5261, Bacterial Pathogenesis and Cellular Responses, Grenoble, France, Université Joseph Fourier-Grenoble I, Grenoble, France, CEA, DSV/iRTSV, Grenoble, France

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  • Published: March 13, 2014
  • DOI: 10.1371/journal.ppat.1003939

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