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Research Article

A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity

  • Laura B Goodman,

    Affiliation: Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

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  • Arianna Loregian,

    Affiliation: Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy

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  • Gillian A Perkins,

    Affiliation: Department of Clinical Sciences, Cornell University, Ithaca, New York, United States of America

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  • Josie Nugent,

    Affiliation: Centre for Preventive Medicine, Animal Health Trust, Newmarket, United Kingdom

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  • Elizabeth L Buckles,

    Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America

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  • Beatrice Mercorelli,

    Affiliation: Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy

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  • Julia H Kydd,

    Affiliation: Centre for Preventive Medicine, Animal Health Trust, Newmarket, United Kingdom

    ¤a Current address: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, United Kingdom

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  • Giorgio Palù,

    Affiliation: Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy

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  • Ken C Smith,

    Affiliation: Centre for Preventive Medicine, Animal Health Trust, Newmarket, United Kingdom

    ¤b Current address: Royal Veterinary College, Department of Pathology and Infectious Diseases, London, United Kingdom

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  • Nikolaus Osterrieder mail,

    To whom correspondence should be addressed. E-mail: no34@cornell.edu

    Affiliation: Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America

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  • Nicholas Davis-Poynter

    Affiliation: Centre for Preventive Medicine, Animal Health Trust, Newmarket, United Kingdom

    ¤c Current address: Herpesvirus Molecular Pathogenesis Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children's Hospital Clinical Medical Virology Centre, University of Queensland, Queensland, Australia

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  • Published: November 09, 2007
  • DOI: 10.1371/journal.ppat.0030160

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