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Research Article

FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling

  • Ali A. Ashkar mail,

    ashkara@mcmaster.ca

    Affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Karen L. Mossman,

    Affiliations: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Brian K. Coombes,

    Affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Carlton L. Gyles,

    Affiliation: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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  • Randy Mackenzie

    Affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Published: December 05, 2008
  • DOI: 10.1371/journal.ppat.1000233

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