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Research Article

Immunization with Single-Cycle SIV Significantly Reduces Viral Loads After an Intravenous Challenge with SIVmac239

  • Bin Jia,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Sharon K. Ng,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • M. Quinn DeGottardi,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Michael Piatak Jr.,

    Affiliation: AIDS and Cancer Virus Program, SAIC Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Eloísa Yuste,

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

    Current address: Retrovirology and Viral Immunology Laboratory, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain

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  • Angela Carville,

    Affiliation: Department of Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Keith G. Mansfield,

    Affiliation: Department of Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Wenjun Li,

    Affiliation: Biostatistics Research Group, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Barbra A. Richardson,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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  • Jeffrey D. Lifson,

    Affiliation: AIDS and Cancer Virus Program, SAIC Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • David T. Evans mail

    devans@hms.harvard.edu

    Affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America

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  • Published: January 23, 2009
  • DOI: 10.1371/journal.ppat.1000272

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