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Research Article

Junín Virus Infection of Human Hematopoietic Progenitors Impairs In Vitro Proplatelet Formation and Platelet Release via a Bystander Effect Involving Type I IFN Signaling

  • Roberto G. Pozner,

    Affiliation: Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina

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  • Agustín E. Ure,

    Affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina

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  • Carolina Jaquenod de Giusti,

    Affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina

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  • Lina P. D'Atri,

    Affiliation: Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina

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  • Joseph E. Italiano,

    Affiliations: Division of Translational Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Department of Vascular Biology, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Oscar Torres,

    Affiliation: Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina

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  • Victor Romanowski,

    Affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina

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  • Mirta Schattner mail,

    mschattner@hematologia.anm.edu.ar (MS); rmg@biol.unlp.edu.ar (RMG)

    Affiliation: Department of Thrombosis and Hemostasis, Hematological Research Institute “Mariano R Castex”, National Academy of Medicine, CONICET, Buenos Aires, Argentina

    These authors are joint senior authors on this work.

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  • Ricardo M. Gómez mail

    mschattner@hematologia.anm.edu.ar (MS); rmg@biol.unlp.edu.ar (RMG)

    Affiliation: Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina

    These authors are joint senior authors on this work.

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  • Published: April 15, 2010
  • DOI: 10.1371/journal.ppat.1000847

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