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Research Article

NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases

  • Bin Wu equal contributor,

    equal contributor Contributed equally to this work with: Bin Wu, Tatiana Skarina

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    X
  • Tatiana Skarina equal contributor,

    equal contributor Contributed equally to this work with: Bin Wu, Tatiana Skarina

    Affiliation: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

    X
  • Adelinda Yee,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    X
  • Marie-Claude Jobin,

    Affiliations: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

    X
  • Rosa DiLeo,

    Affiliation: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

    X
  • Anthony Semesi,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    X
  • Christophe Fares,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    X
  • Alexander Lemak,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    X
  • Brian K. Coombes,

    Affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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  • Cheryl H. Arrowsmith,

    Affiliations: Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

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  • Alexander U. Singer,

    Affiliations: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

    X
  • Alexei Savchenko mail

    alexei.savchenko@utoronto.ca

    Affiliations: Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada

    X
  • Published: June 24, 2010
  • DOI: 10.1371/journal.ppat.1000960

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