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Research Article

Generation of Genic Diversity among Streptococcus pneumoniae Strains via Horizontal Gene Transfer during a Chronic Polyclonal Pediatric Infection

  • N. Luisa Hiller equal contributor,

    equal contributor Contributed equally to this work with: N. Luisa Hiller, Azad Ahmed

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

    X
  • Azad Ahmed equal contributor,

    equal contributor Contributed equally to this work with: N. Luisa Hiller, Azad Ahmed

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

    X
  • Evan Powell,

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

    X
  • Darren P. Martin,

    Affiliation: Computational Biology Group, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

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  • Rory Eutsey,

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

    X
  • Josh Earl,

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

    X
  • Benjamin Janto,

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

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  • Robert J. Boissy,

    Affiliation: Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Justin Hogg,

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

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  • Karen Barbadora,

    Affiliation: Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Rangarajan Sampath,

    Affiliation: Abbott Molecular IbisBiosciences Division, Carlsbad, California, United States of America

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  • Shaun Lonergan,

    Affiliation: Abbott Molecular IbisBiosciences Division, Carlsbad, California, United States of America

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  • J. Christopher Post,

    Affiliations: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania, United States of America, Department of Otolaryngology Head and Neck Surgery, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania, United States of America

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  • Fen Z. Hu mail,

    gehrlich@wpahs.org (GDE) (FH); fhu@wpahs.org (FZH) (GE)

    Affiliations: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania, United States of America, Department of Otolaryngology Head and Neck Surgery, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania, United States of America

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  • Garth D. Ehrlich mail

    gehrlich@wpahs.org (GDE) (FH); fhu@wpahs.org (FZH) (GE)

    Affiliations: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania, United States of America, Department of Otolaryngology Head and Neck Surgery, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania, United States of America

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  • Published: September 16, 2010
  • DOI: 10.1371/journal.ppat.1001108

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