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Research Article

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

  • Aartjan J. W. te Velthuis,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Sjoerd H. E. van den Worm,

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Amy C. Sims,

    Affiliation: Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Ralph S. Baric,

    Affiliation: Departments of Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Eric J. Snijder mail,

    e.j.snijder@lumc.nl (ES); m.j.van_hemert@lumc.nl (MJvH)

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Martijn J. van Hemert mail

    e.j.snijder@lumc.nl (ES); m.j.van_hemert@lumc.nl (MJvH)

    Affiliation: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

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  • Published: November 04, 2010
  • DOI: 10.1371/journal.ppat.1001176

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