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Research Article

Small Molecule Inhibitors of Staphylococcus aureus RnpA Alter Cellular mRNA Turnover, Exhibit Antimicrobial Activity, and Attenuate Pathogenesis

  • Patrick D. Olson,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Lisa J. Kuechenmeister,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Kelsi L. Anderson,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Sonja Daily,

    Affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Karen E. Beenken,

    Affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Christelle M. Roux,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Michelle L. Reniere,

    Affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Tami L. Lewis,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • William J. Weiss,

    Affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

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  • Mark Pulse,

    Affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

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  • Phung Nguyen,

    Affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

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  • Jerry W. Simecka,

    Affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, United States of America

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  • John M. Morrison,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Khalid Sayood,

    Affiliation: Department of Electrical Engineering, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Oluwatoyin A. Asojo,

    Affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Mark S. Smeltzer,

    Affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Eric P. Skaar,

    Affiliation: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Paul M. Dunman mail

    Paul_Dunman@urmc.rochester.edu

    Affiliations: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America

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  • Published: February 10, 2011
  • DOI: 10.1371/journal.ppat.1001287

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