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Research Article

Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

  • Craig B. Wilen,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Jianbin Wang,

    Affiliation: Sangamo BioSciences, Richmond, California, United States of America

    X
  • John C. Tilton,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    Current address: Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, United States of America.

    X
  • Jeffrey C. Miller,

    Affiliation: Sangamo BioSciences, Richmond, California, United States of America

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  • Kenneth A. Kim,

    Affiliation: Sangamo BioSciences, Richmond, California, United States of America

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  • Edward J. Rebar,

    Affiliation: Sangamo BioSciences, Richmond, California, United States of America

    X
  • Scott A. Sherrill-Mix,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Sean C. Patro,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Anthony J. Secreto,

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Andrea P. O. Jordan,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Gary Lee,

    Affiliation: Sangamo BioSciences, Richmond, California, United States of America

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  • Joshua Kahn,

    Affiliation: Sangamo BioSciences, Richmond, California, United States of America

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  • Pyone P. Aye,

    Affiliation: Divisions of Regenerative Medicine and Comparative Pathology, Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, United States of America

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  • Bruce A. Bunnell,

    Affiliation: Divisions of Regenerative Medicine and Comparative Pathology, Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, United States of America

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  • Andrew A. Lackner,

    Affiliation: Divisions of Regenerative Medicine and Comparative Pathology, Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, United States of America

    X
  • James A. Hoxie,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Gwenn A. Danet-Desnoyers,

    Affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Frederic D. Bushman,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • James L. Riley,

    Affiliation: Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Philip D. Gregory,

    Affiliation: Sangamo BioSciences, Richmond, California, United States of America

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  • Carl H. June,

    Affiliation: Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Michael C. Holmes,

    Affiliation: Sangamo BioSciences, Richmond, California, United States of America

    X
  • Robert W. Doms mail

    doms@mail.med.upenn.edu

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Published: April 14, 2011
  • DOI: 10.1371/journal.ppat.1002020

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