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Research Article

A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins

  • Anthony Ryan,

    Affiliation: Immunomodulation Research Group, School of Biotechnology, Dublin City University, Ireland

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  • Mark Lynch,

    Affiliation: Immunomodulation Research Group, School of Biotechnology, Dublin City University, Ireland

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  • Sinead M. Smith,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland

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  • Sylvie Amu,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland

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  • Hendrik J. Nel,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland

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  • Claire E. McCoy,

    Affiliation: School of Biochemistry and Immunology, Trinity College, Dublin, Ireland

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  • Jennifer K. Dowling,

    Affiliation: Immunomodulation Research Group, School of Biotechnology, Dublin City University, Ireland

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  • Eve Draper,

    Affiliation: Immunomodulation Research Group, School of Biotechnology, Dublin City University, Ireland

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  • Vincent O'Reilly,

    Affiliation: Immunomodulation Research Group, School of Biotechnology, Dublin City University, Ireland

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  • Ciara McCarthy,

    Affiliation: Immunomodulation Research Group, School of Biotechnology, Dublin City University, Ireland

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  • Julie O'Brien,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland

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  • Déirdre Ní Eidhin,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland

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  • Mary J. O'Connell,

    Affiliation: Molecular Evolution Group, School of Biotechnology, Dublin City University, Ireland

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  • Brian Keogh,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland

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  • Charles O. Morton,

    Affiliation: Department of Clinical Microbiology, St James Hospital, Trinity College, Dublin, Ireland

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  • Thomas R. Rogers,

    Affiliation: Department of Clinical Microbiology, St James Hospital, Trinity College, Dublin, Ireland

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  • Padraic G. Fallon,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland

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  • Luke A. O'Neill,

    Affiliation: School of Biochemistry and Immunology, Trinity College, Dublin, Ireland

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  • Dermot Kelleher equal contributor,

    equal contributor Contributed equally to this work with: Dermot Kelleher, Christine E. Loscher

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland

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  • Christine E. Loscher equal contributor mail

    equal contributor Contributed equally to this work with: Dermot Kelleher, Christine E. Loscher

    Christine.loscher@dcu.ie

    Affiliation: Immunomodulation Research Group, School of Biotechnology, Dublin City University, Ireland

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  • Published: June 30, 2011
  • DOI: 10.1371/journal.ppat.1002076

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