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Research Article

Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism

  • Kenneth Plante,

    Affiliation: Institute for Human Infections and Immunity, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Eryu Wang,

    Affiliation: Institute for Human Infections and Immunity, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Charalambos D. Partidos,

    Affiliation: Inviragen Inc, Madison, Wisconsin and Fort Collins, Colorado, United States of America

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  • James Weger,

    Affiliations: Inviragen Inc, Madison, Wisconsin and Fort Collins, Colorado, United States of America, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Rodion Gorchakov,

    Affiliation: Institute for Human Infections and Immunity, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Konstantin Tsetsarkin,

    Affiliation: Institute for Human Infections and Immunity, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Erin M. Borland,

    Affiliation: Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America

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  • Ann M. Powers,

    Affiliation: Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America

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  • Robert Seymour,

    Affiliation: Institute for Human Infections and Immunity, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Dan T. Stinchcomb,

    Affiliation: Inviragen Inc, Madison, Wisconsin and Fort Collins, Colorado, United States of America

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  • Jorge E. Osorio,

    Affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Ilya Frolov,

    Affiliation: Department of Microbiology, University of Alabama, Birmingham, Alabama, United States of America

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  • Scott C. Weaver mail

    sweaver@utmb.edu

    Affiliation: Institute for Human Infections and Immunity, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Published: July 28, 2011
  • DOI: 10.1371/journal.ppat.1002142

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