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Research Article

Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies

  • Ben-Jiang Ma,

    Affiliation: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • S. Munir Alam,

    Affiliations: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Eden P. Go,

    Affiliation: Department of Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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  • Xiaozhi Lu,

    Affiliation: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Heather Desaire,

    Affiliation: Department of Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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  • Georgia D. Tomaras,

    Affiliations: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Deparment of Surgery, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Cindy Bowman,

    Affiliation: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Laura L. Sutherland,

    Affiliation: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Richard M. Scearce,

    Affiliation: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Sampa Santra,

    Affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Norman L. Letvin,

    Affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Thomas B. Kepler,

    Affiliation: Center for Computational Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Hua-Xin Liao equal contributor mail,

    equal contributor Contributed equally to this work with: Hua-Xin Liao, Barton F. Haynes

    hliao@duke.edu (H-XL); hayne002@mc.duke.edu (BFH)

    Affiliations: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Barton F. Haynes equal contributor mail

    equal contributor Contributed equally to this work with: Hua-Xin Liao, Barton F. Haynes

    hliao@duke.edu (H-XL); hayne002@mc.duke.edu (BFH)

    Affiliations: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Published: September 01, 2011
  • DOI: 10.1371/journal.ppat.1002200

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