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Research Article

Multidrug Resistant 2009 A/H1N1 Influenza Clinical Isolate with a Neuraminidase I223R Mutation Retains Its Virulence and Transmissibility in Ferrets

  • Erhard van der Vries,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Edwin J. Veldhuis Kroeze,

    Affiliation: Viroclinics Biosciences BV, Rotterdam, The Netherlands

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  • Koert J. Stittelaar,

    Affiliations: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands, Viroclinics Biosciences BV, Rotterdam, The Netherlands

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  • Martin Linster,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Anne Van der Linden,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Eefje J. A. Schrauwen,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Lonneke M. Leijten,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Geert van Amerongen,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Martin Schutten,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Thijs Kuiken,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Albert D. M. E. Osterhaus,

    Affiliations: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands, Viroclinics Biosciences BV, Rotterdam, The Netherlands

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  • Ron A. M. Fouchier,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Charles A. B. Boucher,

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Sander Herfst mail

    s.herfst@erasmusmc.nl

    Affiliation: Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands

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  • Published: September 29, 2011
  • DOI: 10.1371/journal.ppat.1002276

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