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Research Article

Evolution of Multidrug Resistance during Staphylococcus aureus Infection Involves Mutation of the Essential Two Component Regulator WalKR

  • Benjamin P. Howden mail,

    Benjamin.Howden@austin.org.au

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Microbiology Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Christopher R. E. McEvoy,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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  • David L. Allen,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Kyra Chua,

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Wei Gao,

    Affiliations: Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Paul F. Harrison,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

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  • Jan Bell,

    Affiliation: SA Pathology, Womens and Children’s Hospital, Adelaide, South Australia, Australia

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  • Geoffrey Coombs,

    Affiliation: Microbiology Department, Royal Perth Hospital, Perth, Western Australia, Australia

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  • Vicki Bennett-Wood,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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  • Jessica L. Porter,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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  • Roy Robins-Browne,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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  • John K. Davies,

    Affiliation: Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Torsten Seemann,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

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  • Timothy P. Stinear

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Published: November 10, 2011
  • DOI: 10.1371/journal.ppat.1002359

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