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Research Article

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

  • Cheng Huang,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Kumari G. Lokugamage,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Janet M. Rozovics,

    Affiliation: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America

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  • Krishna Narayanan,

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Bert L. Semler,

    Affiliation: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America

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  • Shinji Makino mail

    shmakino@utmb.edu

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

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  • Published: December 08, 2011
  • DOI: 10.1371/journal.ppat.1002433

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