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Research Article

Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA

  • Kouyuki Hirayasu equal contributor mail,

    equal contributor Contributed equally to this work with: Kouyuki Hirayasu, Toshio Yabe

    hirayasu@ifrec.osaka-u.ac.jp (KH); to-yabe@tokyo.bc.jrc.or.jp (TY)

    Affiliations: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, Japan Society for the Promotion of Science, Tokyo, Japan, Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan, Department of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Jun Ohashi,

    Affiliation: Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

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  • Koichi Kashiwase,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Hathairad Hananantachai,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Izumi Naka,

    Affiliation: Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

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  • Atsuko Ogawa,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Minoko Takanashi,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Masahiro Satake,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Kazunori Nakajima,

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Peter Parham,

    Affiliation: Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, California, United States of America

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  • Hisashi Arase,

    Affiliations: Department of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

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  • Katsushi Tokunaga,

    Affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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  • Jintana Patarapotikul,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Toshio Yabe equal contributor mail

    equal contributor Contributed equally to this work with: Kouyuki Hirayasu, Toshio Yabe

    hirayasu@ifrec.osaka-u.ac.jp (KH); to-yabe@tokyo.bc.jrc.or.jp (TY)

    Affiliation: Japanese Red Cross Tokyo Blood Center, Koto-ku, Tokyo, Japan

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.ppat.1002565

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