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Research Article

Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis

  • Karen K. Y. Lam,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

    Current address: NCE CECR PROOF Centre of Excellence, Vancouver, British Columbia, Canada

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  • Xingji Zheng,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Roberto Forestieri,

    Affiliation: Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Aruna D. Balgi,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Matt Nodwell,

    Affiliation: Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Sarah Vollett,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Hilary J. Anderson,

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Raymond J. Andersen,

    Affiliation: Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada

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  • Yossef Av-Gay,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Michel Roberge mail

    michelr@mail.ubc.ca

    Affiliation: Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: May 10, 2012
  • DOI: 10.1371/journal.ppat.1002691

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