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Research Article

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

  • Rebecca M. DuBois,

    Affiliations: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • P. Jake Slavish,

    Affiliation: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Brandi M. Baughman,

    Affiliations: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Mi-Kyung Yun,

    Affiliation: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Ju Bao,

    Affiliation: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Richard J. Webby,

    Affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Thomas R. Webb,

    Affiliations: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Stephen W. White mail

    Stephen.White@stjude.org

    Affiliations: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.ppat.1002830

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Linked Articles

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

Eva Kowalinski, Chloe Zubieta, Andrea Wolkerstorfer, Oliver H. J. Szolar, Rob W. H. Ruigrok, Stephen Cusack
Research Article | published 2 Aug 2012 | PLOS Pathogens
doi:10.1371/journal.ppat.1002831