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Research Article

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

  • Eva Kowalinski,

    Affiliations: European Molecular Biology Laboratory, Grenoble Outstation, BP181, Grenoble, France, Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France

    a Current address: Max-Planck Institute for Biochemistry, Martinsried, Germany

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  • Chloe Zubieta,

    Affiliations: European Molecular Biology Laboratory, Grenoble Outstation, BP181, Grenoble, France, Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France

    b Current address: European Synchrotron Radiation Facility, BP 220, Grenoble, France

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  • Andrea Wolkerstorfer,

    Affiliation: Savira pharmaceuticals Gmbh, Vienna, Austria

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  • Oliver H. J. Szolar,

    Affiliation: Savira pharmaceuticals Gmbh, Vienna, Austria

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  • Rob W. H. Ruigrok,

    Affiliation: Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France

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  • Stephen Cusack mail

    cusack@embl.fr

    Affiliations: European Molecular Biology Laboratory, Grenoble Outstation, BP181, Grenoble, France, Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMI 3265, BP181, Grenoble, France

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.ppat.1002831

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Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

Rebecca M. DuBois, P. Jake Slavish, Brandi M. Baughman, Mi-Kyung Yun, Ju Bao, Richard J. Webby, Thomas R. Webb, Stephen W. White
Research Article | published 2 Aug 2012 | PLOS Pathogens
doi:10.1371/journal.ppat.1002830