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Research Article

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

  • Keith P. Romano,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Akbar Ali,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Cihan Aydin,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Djade Soumana,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Ayşegül Özen,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Laura M. Deveau,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Casey Silver,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Hong Cao,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Alicia Newton,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

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  • Christos J. Petropoulos,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

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  • Wei Huang,

    Affiliation: Monogram Biosciences, San Francisco, California, United States of America

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  • Celia A. Schiffer mail

    Celia.Schiffer@umassmed.edu

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Published: July 26, 2012
  • DOI: 10.1371/journal.ppat.1002832

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