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Research Article

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

  • Luka Cicin-Sain mail,

    luka.cicin-sain@helmholtz-hzi.de (LCS); nikolich@email.arizona.edu (JNZ)

    Affiliations: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany, Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America

    X
  • James D. Brien,

    Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Jennifer L. Uhrlaub,

    Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America

    X
  • Anja Drabig,

    Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany

    X
  • Thomas F. Marandu,

    Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany

    X
  • Janko Nikolich-Zugich mail

    luka.cicin-sain@helmholtz-hzi.de (LCS); nikolich@email.arizona.edu (JNZ)

    Affiliations: Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, United States of America

    X
  • Published: August 16, 2012
  • DOI: 10.1371/journal.ppat.1002849

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Linked Articles

Immune Senescence: Relative Contributions of Age and Cytomegalovirus Infection

Andrea Mekker, Vincent S. Tchang, Lea Haeberli, Annette Oxenius, Alexandra Trkola, Urs Karrer
Research Article | published 16 Aug 2012 | PLOS Pathogens
doi:10.1371/journal.ppat.1002850