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Research Article

Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses

  • Joël T. van Mierlo,

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Alfred W. Bronkhorst,

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Gijs J. Overheul,

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Sajna A. Sadanandan,

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

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  • Jens-Ola Ekström,

    Affiliation: Department of Molecular Biology, Umeå University, Umeå, Sweden

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  • Marco Heestermans,

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Dan Hultmark,

    Affiliations: Department of Molecular Biology, Umeå University, Umeå, Sweden, Institute of Biomedical Technology, University of Tampere, Tampere, Finland

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  • Christophe Antoniewski,

    Affiliation: Drosophila Genetics and Epigenetics, Université Pierre et Marie Curie Paris VI, CNRS UMR 7622 - Biologie du Développement, Paris, France

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  • Ronald P. van Rij mail

    r.vanrij@ncmls.ru.nl

    Affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands

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  • Published: August 16, 2012
  • DOI: 10.1371/journal.ppat.1002872

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