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Research Article

Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate

  • Ruy M. Ribeiro,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    Current address: Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

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  • Hui Li,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Shuyi Wang,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Mark B. Stoddard,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Gerald H. Learn,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Bette T. Korber,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Tanmoy Bhattacharya,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Jeremie Guedj,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Erica H. Parrish,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Beatrice H. Hahn,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • George M. Shaw,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Alan S. Perelson mail

    asp@lanl.gov

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    X
  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002881

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Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome Sequencing

Hui Li, Mark B. Stoddard, Shuyi Wang, Lily M. Blair, Elena E. Giorgi, Erica H. Parrish, Gerald H. Learn, Peter Hraber, Paul A. Goepfert, Michael S. Saag, Thomas N. Denny, ...
Research Article | published 23 Aug 2012 | PLOS Pathogens
doi:10.1371/journal.ppat.1002880